Longevity effects of Fisetin

As we age, some cells in our bodies become damaged and usually die off in a process called autophagy. However some cells do not die when damaged, and instead linger in the body damaging healthy cells by secreting inflammatory substances and growth factors that accelerate aging. These cells are called senescent cells and they play a considerable role in the ageing process. Not only do they damage healthy cells, they also damage stem cells that build and repair organs and tissues. So how can we reduce the amount of senescent cells in our body? This is where Fisetin comes in.

Fisetin is a naturally occurring flavonoid found in fruits and vegetables such as strawberries, apples, grapes, onions and cucumbers. Flavonoids are substances that give fruit and veg their bright colours, and also give them many of their health benefits.

As a senolytic (or a compound that can clear senescent cells), studies have shown that Fisetin is one of the most powerful compounds for eliminating senescent cells and reactivating autophagy – helping to remove toxic elements that accumulate in cells.

Fisetin has been shown to reduce inflammation by increasing the production of other powerful antioxidants that have anti-inflammatory effects. These antioxidants allow cells to repair more effectively. Other benefits of the compound include protecting bone health, supporting brain health, improving skin health as well as its longevity effects.

What are the best sources of of Fisetin?

You can get Fisetin from a range of fruit and veg, or from supplements. Strawberries and apples are some of the best sources, or try our Fisetin supplement – containing 100mg per capsule.

Sources:

https://www.thelancet.com/article/S2352-3964(18)30373-6/fulltext

https://pubmed.ncbi.nlm.nih.gov/16456035/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527824/