As we learn more about the science of ageing and cellular health, two compounds—NMN (Nicotinamide Mononucleotide) and NMNH (Nicotinamide Mononucleotide Hydrogenated)—are gaining attention for their potential to support cellular energy, resilience, and overall wellness. But what sets NMNH apart? And could it offer advantages over NMN in supporting cellular health?

What Are NMN and NMNH?

Both NMN and NMNH are compounds that support the body’s levels of NAD+ (Nicotinamide Adenine Dinucleotide), an essential molecule involved in cellular energy production and various metabolic functions. NAD+ is known to decline with age, which can negatively impact energy levels, cellular repair, and overall vitality.

NMN and NMNH are both precursors of NAD+, meaning they provide the building blocks that help increase NAD+ levels within cells. However, NMNH is a more recently studied form and is believed to offer unique advantages due to its chemical structure and the way the body absorbs it.

How Does NMNH Differ from NMN?

The main difference between NMN and NMNH lies in the addition of a hydrogen atom, which influences its stability and bioavailability in the body.

Stability: NMNH is a hydrogenated form of NMN, which helps protect it from degradation in the body. This added stability means that more of the compound may remain available for conversion into NAD+, potentially leading to greater effectiveness.

Bioavailability: Studies suggest that NMNH has higher bioavailability than NMN, meaning it’s more readily absorbed into cells. Enhanced bioavailability can improve the efficiency of NAD+ production, supporting cellular health more effectively than NMN.

NAD+ Conversion Efficiency: Studies have also indicated that NMNH converts to NAD+ more directly than NMN, potentially making it a more efficient NAD+ booster overall.

Benefits of NMNH Over NMN

With its advantages in stability, bioavailability, and conversion efficiency, NMNH offers several potential benefits over NMN:

Enhanced Cellular Energy Production

NAD+ plays a crucial role in cellular energy production. In clinical studies, NMNH has demonstrated a nearly five-fold increase in cellular NAD+ levels, when compared to NMN. By boosting NAD+ levels more effectively, NMNH may support a more sustained and reliable increase in cellular energy, which could improve overall vitality and endurance.

Improved Cellular Repair and Anti-Ageing Effects

Higher NAD+ levels are associated with improved cellular repair mechanisms, helping cells recover from damage and combat oxidative stress, which contributes to ageing. Since NMNH may convert more efficiently to NAD+, it appears to be a stronger candidate for those looking to support anti-ageing processes and cellular resilience.

Greater Mitochondrial Support

NAD+ is essential for mitochondrial health, as it helps power these “energy factories” within our cells. NMNH’s potentially higher bioavailability could mean more robust mitochondrial support, which is vital for overall metabolic health and the prevention of age-related decline.

Sustained NAD+ Increase – 20 hours

Clinical studies have documented the NAD+ increase from NMNH lasting as long as 20 hours, compared to the 1-2 hour peak observed with NMN.

Final Thoughts: Is NMNH Right for You?

The science behind NMNH suggests that it may offer unique advantages over NMN for those looking to boost NAD+ levels more effectively. Its stability, bioavailability, and efficient conversion to NAD+ could make it a valuable addition to a well-rounded approach to cellular health and longevity.

For individuals aiming to support cellular energy, resilience, and overall wellness, NMNH could be a compelling option. However, as with any supplement, it’s essential to stay informed about ongoing research and consult a healthcare professional to ensure it’s a safe fit for your individual needs.

Summary

NMNH is a more stable and potentially more bioavailable form of NMN, making it potentially more efficient in raising NAD+ levels.

Higher NAD+ levels can support cellular energy, repair, mitochondrial health, and anti-ageing.

While current research on NMNH shows promise for longevity, consulting a healthcare professional is advisable before use, especially if you have any health conditions or are on medication.

Ultra NMNH (Dihydronicotinamide Mononucleotide) – 10X Increase in NAD+ Levels – Cellular Energy & Longevity – Made with Premium UTHPEAK®

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Sources:

Zapata-Pérez R, Tammaro A, Schomakers BV, et al. Reduced nicotinamide mononucleotide is a new and potent NAD⁺ precursor in mammalian cells. The FASEB Journal. 2021; 35:e21456. 

Liu Y, Luo C, Li T, Zhang W, Zong Z, Liu X, Deng H. Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD⁺ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth. J Proteome Res. 2021 May 7;20(5):2596-2606. doi: 10.1021/acs.jproteome.0c01037. Epub 2021 Apr 1. PMID: 33793246.